![]() We hypothesized that increasing IGF1 levels strictly in macrophages will prevent atherosclerosis.Īfter breeding a novel macrophage-specific IGF1 overexpressing transgenic mouse to an Apoe -/- background (MF-IGF1 mice), we assessed atherosclerotic plaque burden, stability, and monocyte recruitment. Results of our previous in vitro experiments suggest that macrophages play a predominant role in mediating IGF1 effects in atherosclerotic plaque, but exact mechanisms remain unclear. IGF1 administration in ApoE deficient (Apoe -/-) mice fed a high fat diet reduced atherosclerosis and reduced plaque macrophages. Insulin Like Growth Factor I (IGF1) has been shown to reduce cardiovascular events. We've got your morning reading covered.1Tulane University School of Medicine, New Orleans, LAĢUniversity of Missouri System, Columbia, MOĪtherosclerosis is the leading cause of Cardiovascular Disease, which is still the global leader of mortality. Related: Most '90s Sitcoms Could Be Rebooted As Dramas Get the Cracked Daily Newsletter! Subscribe to our YouTube channel, and check out The 8 Most Unintentionally Hilarious Amateur Music Videos, and other videos you won't see on the site!Īlso, follow us on Facebook, and let's be best friends forever. ![]() Have a story to share with Cracked? Email us here.įor more insider perspectives check out 5 Horrifying Things Real Dead Bodies Do (Too Weird For TV) and 5 Horrifying Truths About Funeral Homes (From An Undertaker). Follow him on Twitter for stuff cut from this article and other things no one should see. Ryan Menezes is an editor and interviewer here at Cracked. That reaction seems Hollywood-caliber extreme to most of us, but maybe that's because we don't have anybody who loves us enough to go Pentecostal at our passing. before the funeral home arrived to pick up the body and those distraught family members started to leave. The staff nurse was questioned about why towels were being used instead of wound care supplies, and she replied, "She's going on hospice, so it shouldn't make any difference." When you're going to die, some people take that as license to treat you like you're already dead. In fact, the director was appalled by the situation. I notified the director of nursing, and miraculously, I wasn't fired this time. She had, in the least-metaphorical sense, ripped herself a new asshole, and this facility was using rolled-up hand towels to pack the wound. I found she had a Stage 4 pressure ulcer on her right buttock. In one nursing home, I examined another dementia patient, bed-bound and unable to speak or move herself. I went on nursing elsewhere, where I saw other patients suffering all kinds of abuse. Patient care industries don't always have a stellar record with that kind of thing. Obviously, I wrote up this incident and notified the director of nursing. Having a feeding tube sucks enough without it killing you in the process. ![]() Trust me, "rotting from the inside out via spoiled Ensure" is not the best way to go. With feeding tubes, the solution may do nothing but sit in your stomach, which puts you at risk for a severe infection that'd kill you faster than if you'd done nothing. Your body may not do anything with the fluid, which means the water could accumulate and result in acute heart failure. Relatives might suggest attaching an IV, but I (and hopefully the doctor) will discourage this. When your health starts to decline, you'll likely refuse food and water anyway. But the drying-out process can start long before the loss of consciousness sets in. That's why many people don't actually die of their illness - they die of dehydration. In your last days, you'll be so divorced from consciousness that you'd drown on a sip of water. Those hospital cats that can predict when patients die? They don't have Miriam Black psychic powers they simply have a heightened sense of smell. Also, much like pancakes, you give off a sweet smell - the result of acidosis, or the breakdown of internal sugars. Surprisingly, it's bad news if we don't hear the rattle anymore that means you have the approximate shelf life of pancake batter.
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